One teenager has died and another is in hospital following a collision in Stalybridge on Tuesday evening (3 November).
Greater Manchester Police say they were called to a report of an attempted burglary on Ambleside just after 6pm.
On arrival, officers began to follow a vehicle they believed to be involved in the incident.
The car, a VW Golf, later collided with a wall on Wakefield Road at around 6.30pm.
Emergency services attended but the driver, a 16-year-old boy, was pronounced dead at the scene.
A second teenager, a 16-year-old passenger, was taken to hospital by paramedics in a serious condition.
Police say enquiries are ongoing and a cordon is in place whilst an investigation takes place.
Anyone with information is asked to call 101, quoting incident number 2146 of 03/11/20.
GMP say the incident has been referred to the force's Professional Standards Branch and the Independent Office for Police Conduct (IOPC), in line with standard procedure.
A statement from IOPC confirmed an investigation has been launched.
It says: "We have begun an independent investigation into the actions of the police prior to a collision in Stalybridge in which, sadly, the 16-year-old driver of a car has died and another 16-year-old was seriously injured.
"We were notified by Greater Manchester Police (GMP) that at around 6.30pm on Tuesday 3 November in Wakefield Road that a police vehicle had followed a car and shortly afterwards found it had crashed near the junction with Printworks Road.
"Our investigators are attending the scene of the collision and the post-incident procedures.
"Our thoughts are with the families of the two 16-year-olds and all of those affected.