The young Millers face two away games before a local derby against Glossop following confirmation of September's fixtures.
The North West Under 21 Development League have released the opening fixtures for the 2019/20 campaign.
New Mills start the season this weekend with a trip to Tytherington on Sunday before travelling to Bacup Borough a week later (15 September).
The following Sunday sees the Millers' first home game, when Glossop North End visit Church Lane for a mouthwatering local derby.
They then end September by hosting Pro Ethical Elite Academy on the 29th.
All matches will kick off at 2pm.