Roundthorn Primary Academy in Oldham has closed after two of its staff members have tested positive for coronavirus.
The Roundthorn Road school will shut for at least two weeks as a result - due to staff shortages and to allow a deep clean to take place.
Other staff members are also showing symptoms and self-isolating at home.
A letter sent home to parents on Tuesday by executive principal John Taylor said: "It is with regret that we must close the school today for a period of at least 14 days.
"This is because two members of staff are confirmed to have coronavirus and others are showing symptoms and self-isolating at home.
"As your child's health and safety is our highest priority, we do not have enough staff to maintain safe adult to pupil ratios within school.
"During this time we will ensure that there is a deep clean throughout the school and if possible, open at the end of this period of time.
"As you will be aware, the national picture is changing each day, so we will keep you updated via the text messaging service, the school website and social media.
"Any decision to close a school is never taken lightly, but in the current circumstances we believe it to be the safest course of action.
"Your child has been sent home with some activities that they can do at home as well as some links to online learning opportunities."
There are currently 10 confirmed cases of coronavirus in Oldham, according to Public Health England figures.